Value of AgNOR, in Malignant Lesions of Cervix

AUTHORS : Sonowal Basanta, Handique Amitabh
DOI No. : 09.2016-41461927

ABSTRACT :
Objectives: To evaluate the correlation of AgNOR count and malignant lesions of cervix. Methods: The material for the study was collected from patient with various lesions of cervix. After colposcopy, a cervical biopsy was done. Routine paraffin sectioning was done for these biopsy specimens. Histopathologic diagnosis was first established on these sections using the routine (H & E) stain. Then, further sections were cut from prepared blocks and were subjected to AgNOR staining technique. AgNOR count was taken as the mean number of black dots per 100 cells observed under a 100× oil immersion objective. Results: In this series biopsy specimens were obtained and subjected to routine method of haematxoylin and eosin staining which revealed 25% to be benign and 26.6% to be cervical intraepithelial neoplasia and 48.4% cases to be carcinoma. Conclusion: The results of the AgNOR when used can provide strength to the clinician and histopathologist in diagnosing early carcinoma in cases of suspicious cervix.

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