Erythrocyte Plasma Membrane Redox System, Plasma Vitamin C and Protein Carbonyl in Carcinoma Cervix Patients

AUTHOR(s) : Banerjee Ivy, Mukherjee Amrita, Lahiri Surajit, Rout Jayanta Kumar, Ghosh Debdutta, Sarkar Chandan
DOI No. :

Introduction: Though cervical cancer is a multi-factorial disease, the importance of oxidative stress in the pathogenesis cannot be underestimated. Methods: 40 cervical cancer patients (10 patients of each stage) and 40 age matched female controls were recruited for the study. Plasmaascorbate, protein carbonyl and erythrocyte plasma membrane redox system (PMRS) were studied in each subject. Results: Compared to controls plasma protein carbonyl and erythrocyte plasma membrane redox system are significantly higher and plasma ascorbate is significantly lower in cervical cancer. Conclusion: For the first time we have showed significant increase of erythrocyte PMRS activity in cervical cancer to mitigate oxidative stress in the body.

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