Impact of adverse drug reactions on quality of life in patients with schizophrenia

AUTHORS : Chakravarty Pinaki1 , Neog Parthajyoti2 , Roy Dolly3
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To monitor the adverse drug reactions of antipsychotic drugs used in patients with schizophrenia in the outpatient department of psychiatry & to find out the impact of adverse drug reactions on quality of life in those patients. Methodology: A prospective observational study was carried out in the outpatient department of psychiatry. New patients with schizophrenia and above 18 years of either sex with only one antipsychotic drug were included. ADRs reported spontaneously by the patients and also responses obtained in a questionnaire related to the likely ADRs from the patients were recorded in the case record form. QOL was assessed with the help of World Health Organization Quality of Life-BREF questionnaire method and scoring system at the beginning and after 1 month. Results: The incidence of ADR was 64.78% in males and 35.21% in females. Weight gain was the most common ADR observed. The psychological health is mostly affected by ADRs. A low QOL was noted in all patients with ADRs. Conclusion: Atypical antipsychotics are frequently used to treat schizophrenia. It is due to their better patient compliance and high margin of safety compared to typical antipsychotics.

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