Concomitant fungal infections in patients of pulmonarytuberculosis attending respiratory medicine OPD

AUTHORS : Deka Bhakhita, Borgohain Parismita, Barua Purnima
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Introduction: Fungal infections are frequently encounteredin clinical practice; especially the incidence of concomitantfungal infection has been increasing amongimmunocompromised patients. Present study was carriedout to identify of fungal pathogens from sputum sample ofpulmonary tuberculosis patients and to assess and determinethe prevalence of different fungal pathogens in pulmonarytuberculosis patient. Materials and methods: A total of 100pulmonary tuberculosis patients were interviewed using pre-tested questionnaires and direct mount and culture of sputumwas performed for each. Results: Of 100 patients, thecommonest were in the age group 31-40 years (n= 29,29%) followed by age group 41-50 years (n=22, 22%).Majority of participants were tea garden workers (n=36,36%) followed by daily wage workers (n=14, 14%). It wasobserved that 26% (n=26) were KOH positive and culturepositive; 1% (n=1) was KOH negative and culture positive;30% (n=30) were KOH positive and culture negative; 43%(n=43) were both negative. Highest co infection was withC. albicans (n=15, 68.18%) followed by C. tropicalis (n=4,18.18%). Prevalence of mycotic co infection was highest inMulti-drug Resistant TB (MDR-TB) (60%) followed byCategory II (35.71%) than Category I (19.40%) DOTSrecipients. The prevalence of fungal infection in male smokerswas found to be statistically significant (P<0.05).Conclusion: Mycotic confection in patients with pulmonarytuberculosis is inevitable. Adequate measures need to betaken for the accurate identification and treatment of theseopportunistic infections, which are associated with high ratesof morbidity and mortality.

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