Clinicopathological profile of patients with up-front metastaticbreast cancer: a study from North East India

AUTHORS : Mahanta Neelakshi, Deka Hitesh, Kalita NK, Niharika Kutum, Lokkur PP, Ali AS
DOI No. : 10.31741/ijhrmlp.v6.i2.2020.2

ABSTRACT :
Introduction: Breast cancer is the most common cancer in Indian females and approximately 5-10% present with up-front metastasis and 20-30% patients develops metastasis during follow up, but still limited data is available regarding the same. Objectives: To study the clinicopathological profile of breast cancer patients presenting with up-front metastasis.Materials and methods: This is a retrospective study of Metastatic Breast Cancer (MBC) patients who attended the medical Oncology Department of State Cancer Institute, Guwahati. In the study, we reviewed the records regarding clinical and histological profile, receptor status and site of metastasis of breast cancer patients presented with up-front metastasis from January 2019 to December 2019. Results: Total of 65 cases of MBC were studied. The average age of presentation was 46 years (range 22-70 years) with an average duration of symptoms 8 months (range 3-18 months). Male and Female ratio was 2:63. MBC was common in post-menopausal (52.38%) and Para 2 (48.7%) women. 41.53%of patients were at performance status 1 at presentation. In the histopathological study, ductal carcinoma was the most common (93.85%) pathological type with Nottingham grades (60%) was the most common. Baseline receptor status suggested that 56.92% were hormone receptor [HR] positive,40% were human epidermal growth factor-2 [Her2] positive and 18.46% were triple-negative breast cancer[TNBC]. Various sites of metastasis were visceral only (20%), bone (40%), combined bone and visceral (36.92%), non-regional lymph nodes (15.38%) and brain (4.61%). Conclusion: MBC is common in younger patients with bony metastasis being the commonest site of metastasis.
Keywords: Histopathological profile; receptor status; sites of metastasis.


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