Histomorphological spectrum of prostatic lesions and theircorrelation with serum prostate-specific antigen level

AUTHORS : Rashid N, Dutta UC, Rahman MLA, Hassan SW
DOI No. : 10.31741/ ijhrmlp.v6.i2.2020.3

ABSTRACT :
Background: Prostate Specific Antigen (PSA) estimation is elevated in patients with prostate enlargements including prostatic diseases, surgical procedures, benign hyperplasia and prostatic malignancy. A significant increase of PSA has been correlated with prostatic cancer and as such the same parameter has been widely used in the diagnosis and management of prostatic cancer. Objective: The objective of the study was to determine the relationship between serum PSA levels and histological findings in biopsy specimens of prostatic lesions. Materials and methods: This study includes patients planned for prostatectomy. Blood samples were collected preoperatively and tested for PSA. Histology of the tissue samples collected after Trans Urethral Resection of Prostate (TURP) was studied and the relationship with PSA analyzed. The study pertains to the utility of PSA assay in different Prostatic lesions including carcinoma of Prostate. Results: 71 patients were included in the study. There were59(83.10%) benign cases,7(9.86%) cases of ProstaticIntraepithelial Neoplasia (PIN) and 5(7.84%) cases of adenocarcinoma (Adenoca) of the prostate. Serum PSA values were analyzed in different prostatic lesions like; Nodular Hyperplasia of Prostate (NHP), High-Grade ProstateIntraepithelial Neoplasia (HGPIN), Adenocarcinoma, etc. Conclusion: The study showed a statistically positive correlation between histological diagnosis and serum PSA. In all cases of malignancy, Gleason score was correlated with serum PSA values. However, the present study did not reveal any correlation between the two variables.
Keywords: Gleason’s score; carcinoma; prostatitis.


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