Assessment of event-related potential P300 amongst people with type-2 diabetes and normal individuals

AUTHOR(s) : Vijayadas, Saha S, Preethi BL, Kalra P
DOI No. : 10.31741/ijhrmlp.v8.i1.2022.9



Background and aims: Type-2 diabetes mellitus (DM) is a complex metabolic disorder that has a detrimental effect on almost all human body systems. This study assessed and compared the cognitive function of normal subjects and individuals with type-2 diabetes. Material and methods: The study included 15 type-2 diabetics and 15 healthy controls between 20-50 years. P300 was recorded using the standard auditory odd-ball paradigm from the vertex (Cz&Pz) in response to stimuli presented through headphones. The peak latencies of P300 of target stimuli (rare) were calculated. Results: P300 latencies were significantly prolonged in the case of type2 diabetes mellitus compared to normal individuals. With the increase in HbA1c level, P300 latencies were increasing. Conclusion: An increase in latencies of P300 indicates the presence of a cognitive decline in type-2 diabetics. Our study showed an early onset of cognitive decline, which increased with increasing HbA1c levels.

Keywords: Type 2 diabetes mellitus; cognition.

Vijayadas, Saha S, Preethi BL, Kalra P. Assessment of event-related potential P300 amongst people with type-2 diabetes and normal individuals.Int J Health Res Medico Leg Prae 2022 Jan-June;8(1): X-Y. Doi:

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